Knowledge base
Archived articles from Synergus RWE, kept for reference.
37 articles
Danish Real World Data sources - National Registries
Denmark provides several national registries and disease / intervention registries. One of the unique benefits that Denmark provides is the speed of access. In best case scenario, data can be provided in 2 months. One…
Finnish Real World-World data sources – National registries
Finnish Real World-World data sources – National registries Finland provides a broad range of national Real-World-Data set that can be utilized for research. Below is a summary of the most essential data-sets, including…
Swedish Real-World data sources – National registries
Swedish Real-World data sources – National registries This is the first blogpost in a series about the available Real-World Data sets in Sweden focusing on the national registries. Seamless linkage is essential To…
The best real-world data setting for diabetes research – How much data is required?
The Swedish setting provides an extremely rich data set with very high quality for diabetes research. The foundation is the national diabetes registry (NDR) that covers 92,7% of all patients in the country diagnosed…
More than 60 data-sets in England for real-world evidence
More than 60 data-sets in England for real-world evidence Many are aware of the CPRD data-set and Hospital Episode Statistics (HES) which indeed are valuable. However, there are more than 60 data-sets in England for…
Transferring Outcomes Data: The Illusion of Simplicity - Variation in stroke health outcomes and healthcare delivery
This blogpost takes stroke care as an example to demonstrate the differences observed in health outcomes and resource distribution, 1-year post-stroke. This example is based on data from Sweden, categorized by region.…
Transferring Outcomes Data: The Illusion of Simplicity - A Case Study comparing Breast Cancer outcomes and care delivery
Breast Cancer – Part 3 In this blog series we are analysing different aspects of the transferability of disease outcomes, either from RCT to Real-World setting or between different settings/countries. If you missed the…
Transferring Outcomes Data for National Decision Making: The Illusion of Simplicity - The whole world should use validated Swedish Data, or maybe not….
This blog is part of our series on the issues related to the transferability of outcomes, for national decision making. You can follow this link to read our other blog posts on this topic. The ongoing discussion about…
Transferring Outcomes Data for National Decision Making: The Illusion of Simplicity What is the HTA perspective on transferability?
This is a blog in our series about the issues relating to the transferability of outcomes for national decision making. Click on this link to get the other posts related to this topic. In this blog post we will provide…
Transferring Outcomes Data for National Decision Making: The Illusion of Simplicity
Variation in outcomes and health care delivery Breast Cancer – Part 2 In this blog-post series we are analysing different aspects about transferability of outcomes, either from RCT to Real-World setting or between…
Transferring Outcomes Data for National Decision Making: The Illusion of Simplicity - Understanding why healthcare delivery is a significant issue
This blog is part of our series on the issues related to the transferability of outcomes, for National decision making. You can follow this link to read our other posts within this topic. To illustrate the impact and…
Transferring Outcomes Data: The Illusion of Simplicity
As previously announced , we have started a project that will look at issues relating to “Methodological aspects of evaluating transferability of Real World Evidence results between countries / settings”. As part of…
CPRD – Probably the most utilized data-set in Europe for Real World Evidence studies?
More than 2300 scientific publications have been generated from the CPRD database. This would probably make it the most utilized data-set for RWE research. As of September 2019, 1600+ GP practices in the UK have…
Mortality and Cause of death variable in Oncology
Context of blog – European Payer perspective While developing this blog, I realized how important it is to clarify the perspective with which you review a certain question. My perspective, even though initially not…
Flatiron vs Sweden – How does the oncology data registers compare?
The potential use of data from Flatiron to support regulatory and reimbursement applications in oncology has stirred up quite an interest in the field. The current developments we have been seeing prove the potential of…
13 quality registries in Sweden with more than 90% coverage
The ministry of health is regularly reviewing the quality of the data in the quality registries. In this latest review they reviewed 42 quality registries (out of more than 100). 13 of these registries has a coverage…
Supporting medicines for children in the EU: Clinical trials and RWE
The European Medicines Agency (EMA) recently released a report into the differences of medications and medicines on children and infants. The Paediatric Regulation, which was introduced in 2007 and requires…
There is more than one validated RWD data source!?
In a recent tweet from the International Society for Pharmacoepidemiology (@ICPE) it was stated from a company that they had the only validated real-world evidence platform that enables reproducible, transparent safety…
Norwegian real-world evidence: CNS Disorders
Norway not only has a rich source of oil but has a rich supply of real world data sources (RWDs), especially when in concerns the central nervous system! Such registries have been used for a number of studies and…
Norwegian real-world evidence: Oncology
Norway not only has a rich source of oil but has a rich supply of real world data sources (RWDs), especially when in concerns oncology! Such registries have been used for a number of studies and publications. This is…
Comparability, Completeness and Validity: the Norwegian Cancer Registry Data
Decision makers are generally used to evaluating data according to its internal validity, as has been the case for RCTs, however by doing this, understanding for the specifics for a disease or intervention can be…
Norwegian real-world evidence
Norway has a rich of real world data sources, which have been used for research and publications. When we focus on Norway’s mandated/national registries, we find a rich source of interesting and varied high-quality…
Registries for shunt implantation
We believe that real world evidence is a significant question for the future. However there is a challenge to identify the available data-sets and the scientific evidence generated. We are in the process to develop a…
Where is the best quality real world data regarding Atrial Fibrillation in Europe?
The aim of our review is to uncover which real world datasets, based on patient / disease based registries, exist in Europe regarding atrial fibrillation . We also aim to understand how these differ in the ability to…
Stuck in DRG/ZE negotiations in Germany?
Many medical device manufacturers have found themselves caught in a trap where there is a DRG and/or ZE (add-on payment) available for their technology but where the insurance companies refuse to pay this fee. Through…
Where is the best quality real world data regarding Rheumatoid Arthritis in Europe?
The aim of our review is to uncover which real world datasets, based on patient / disease based registries, exist in Europe regarding rheumatoid arthritis . We also aim to understand how these differ in the ability to…
Where is the best quality real world data regarding Stroke in Europe?
The aim of our review is to uncover which real world datasets, based on patient / disease based registries, exist in Europe regarding stroke. We also aim to understand how these differ in the ability to conduct outcomes…
Where is the best quality real world data regarding MS in Europe?
The aim of our review is to uncover which real world datasets, based on patient / disease based registries, exist in Europe regarding MS. We also aim to understand how these differ in the ability to conduct outcomes…
Overview of registry based randomized clinical trials
In our journey to create insight in the utility, we have made a search for registry based randomized clinical trials. Below is a summary of what we have identified so far. We will continue to updated the list as we…
Value-based health care in stroke
This is a summary of the pilot study regarding the development of a value-based monitoring platform for stroke care in Sweden. Initial analysis of data To understand the relevant outcomes, historical data from 2010 on…
Where is the best quality real world data regarding Diabetes in Europe?
The aim of our review is to uncover which real world datasets, based on patient / disease based registries, exist in Europe regarding diabetes. We also aim to understand how these differ in the ability to conduct…
Where is the best quality real world data regarding Breast Cancer in Europe?
The aim of our review is to uncover which real world datasets, based on patient / disease based registries, exist in Europe regarding breast cancer. We also aim to understand how these differ in the ability to conduct…
Where is the best quality real world data regarding Heart Failure in Europe?
The aim of our review is to uncover which real world datasets, based on patient / disease based registries, exist in Europe regarding heart failure. We also aim to understand how these differ in the ability to conduct…
Which European country has the best quality Real World Data for specific diseases / intervention?
We have started several projects that aim to understand which patient / disease registries have the ability to be used in outcomes research. Even though the title would imply a broader perspective, our current focus is…
A registry-based randomized clinical trial for heart failure treatment using the Swedish Heart Failure Registry
Electronic health records and clinical cardiovascular quality registries provide opportunities for pragmatic clinical trial (PCT) and registry-based prospective randomized clinical trials (RRCTs). Simplified regulatory,…
Registry based Randomized Clinical Trials with significantly lower cost. The method for the future?
The randomized clinical trial (RCT) is a powerful tools for clinical researchers, which evaluates the effectiveness of new (or established) treatments while accounting for the effects of unmeasured confounders and…
The ability to demonstrate savings in the real world is very relevant for payer
The value of real world data is frequently debated. This is very much dependent on the perspective of the person who is reviewing the data. If you are able to use real world data to demonstrate to a payer that they can…