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Health-state utility estimates for health technology assessment: a review of the manufacturers’ submissions to the French National Authority for Health

Authors from the National Authority for Health (HAS) published a review on the selection and methods used for deriving health state utility (HSU) estimates included in the cost-utility analyses (CUA) submitted by manufacturers to the HAS (34 CUA in total) during the first 2 years after the introduction of the economic evaluation for price setting in France.
A literature review to identify HSU was reported in only 13 (38%) submissions. The instruments for describing HSU were:

  • a preference-based generic instrument in 20 (59%) submissions
  • vignettes in 5 (15%)
  • a condition-specific instrument in 3 (9%)
  • and a combination of instruments in 6 (18%)

The valuation perspective was the general population in 26 (76%) submissions; in only nine (26%) submissions, the valuation set was derived from the French general population.
The authors concluded that most submissions (79%) included HSU that did not meet HAS recommendations.